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A novel agglomeration technique, termed "Spherical Crystallization Process", which can transform directly the fine crystals produced in the crystallization or the reaction process into a spherical shape was developed. By this technique, needle like crystals such as salicylic acid were transformed into free flowing and directly compressible agglomerates. Spherically agglomerated aminophylline crystals were obtained directly from the reaction system, which could reduce the preparation processes, e.g. synthesis, crystallization and agglomeration, into only one step. Sodium theophylline monohydrate agglomerates were prepared by salting out, the rate process of which was described by a first order kinetics. Agglomerated crystals of new complex of indomethacin-mepirizole were prepare with this technique; an improved therapeutic effect of the resultant crystals was expected.
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